STAT3与子宫内膜癌关系及分子靶向治疗的研究进展

摘要

STAT3（ signal transducer and activator of transcriPtion 3）是一种存在于细胞质中的转录因子，是多条致癌信号转导通路的汇集点。在各种细胞外信号作用下STAT3在多种肿瘤中呈异常激活，通过修饰靶基因的表达，调节细胞增殖、分化及凋亡，与子宫内膜癌的发生、发展、侵袭、转移及预后密切相关，可作为早期诊断及判断预后的指标。近年来子宫内膜癌研究中针对STAT3通路的分子靶向治疗取得了很大进展。%Signal transducer and activator of transcriPtion 3(STAT3)is a kind of transcriPtion factor which exist in the cytoPlasm,is a collection Point multiPle signal transduction Pathway in cancer,under the action of a variety of ex-tracellular signals STAT3 Presents abnormal activation in a wide variety of tumor assumes,regulates cell Proliferation,differentiation and aPoPtosisby by modifying the exPression of target genes,STAT3 closely related with the occurrence, develoPment,invasion,transfer and Prognosis of endometrial carcinoma,can be used as an index to early diagnosis and Prognosis,Provide new target for theraPy. In recent years the study on molecular targeted theraPy of STAT3 Pathway made great Progress in endometrial carcinoma.