凋亡相关基因p53和bax在基底细胞样乳腺癌中的表达及意义

摘要

Objective:To investigate the expression of p53 and bax in basal-like breast carcinoma( BLBC)and the relationship between them. Methods:The expression of p53 and bax was detected in 43 cases of BLBC,57 cases of non-BLBC and 60 cases of normal breast tissue by immunohistochemistry. Results:The positive rates of p53 in BLBC,non -BLBC and the normal breast tissue were 79. 07%(34/43),52. 63%(30/57),5. 00%(3/60)re-spectively,and compared with each other,p were all less than 0. 01. The expression of bax were 20. 93%(9/43), 45. 61%(26/57),76. 67%(46/60)respectively,and compared with each other,p were all less than 0. 01. The ex-presion of p53 and bax in BLBC were correlated with lymphnodes metastasis and pTNM staging of BLBC ,p were all less than 0. 05. There was negative correlation between the expression of p53 and bax in BLBC(r= -0. 578,p﹤0. 01). Conclusion:The expression of p53 was higher and the expression of bax was lower,the abnormal expressions of p53 and bax were correlated with occurrence and development of BLBC.%目的：探讨p53和bax在基底细胞样乳腺癌中的表达及相互关系。方法：应用免疫组化方法检测43例基底细胞样乳腺癌（ basal-like breast carcinoma，BLBC），57例非基底细胞样乳腺癌（ non-BLBC），60例正常乳腺组织中p53和bax的表达。结果：p53在BLBC、non-BLBC和正常乳腺组织中的阳性表达率分别为79.07%（34/43）、52.63%（30/57）、5.00%（3/60），两两比较，p均﹤0.01；bax的阳性表达率分别为20.93%（9/43）、45.61%（26/57）、76.67%（46/60），两两比较，p均﹤0.01。p53和bax在BLBC中的表达水平与患者淋巴结转移情况及临床分期相关，p均﹤0.05，p53与bax在BLBC中的表达呈负相关（ r＝-0.578，p﹤0.01）。结论：BLBC组织中p53表达升高，bax表达降低，两者异常表达可能与BLBC的发生、发展密切相关。