人附睾蛋白4在子宫内膜癌诊断与治疗中的研究进展

摘要

Endometrial carcinoma lack of sensitive and distinctive tumor marker,human epididymis protein 4(HE4) is the new tumor marker found in recent year. The gene of HE4 is first discovered in human epididymis epithelium cell. A study demonstrates that the high level of HE4 was found in endometrial carcinoma cells from all kind of tumor tissues. HE4 is affected by various factors,except for pathema and region,we also need define the clinical reference ranges according to the age group and race. Compared with CA125,for the diagnosis,the prognosis,the curative effect observation,and the surgical resection extent of endometrial carcinoma,HE4 has more important significance. In this review,we summarize the research progress of HE4 in the diagnosis and treatment of endometrial carcinoma.%子宫内膜癌患者缺乏敏感性及特异性均高的血清肿瘤标志物，人附睾蛋白4（ human epididymis protein 4，HE4）是近年发现的新肿瘤标志物，HE4基因最早是在人附睾上皮细胞中被发现的。研究发现，在子宫内膜癌细胞中检测到高水平的血清HE4。但HE4受多方面因素影响，除疾病、地域等因素外，仍需根据年龄及种族，界定血清HE4的临床参考范围。相比CA125，HE4有高的敏感性，而对于早期子宫内膜癌，更具有诊断价值，同时在子宫内膜癌的预后判断、疗效检测以及决定手术范围等方面都具有一定的意义。现就HE4在子宫内膜癌诊断与治疗中的研究进展进行综述。