Melanoma is a kind of malignant tumor that derived from the melanocytes which often located in skin,mu-cous membrane,eye and pigmentation area of the central nervous system. Although the incidence of malignant melano-ma is not high,it is characterized by high malignant degree because of its early invasion and metastasis which lead to patients have poor prognosis. At present,the comprehensive treatment strategy for malignant melanoma including sur-gery,radiotherapy,chemotherapy and Chinese traditional medicine,however,surgical treatment still remains the first choice for early stage patient,however,studies related to Chinese medicine treatment of melanoma is still in its infan-cy. In recent research,they demonstrate that curcumin which is the active ingredient of zingiberaceae plants,turmeric, rhizoma zedoariae,etc,has extensive pharmacological properties of anti - cancer,anti - inflammatory and antioxidant, especially the potential utility in tumor prevention and treatment. Curcumin can inhibit the proliferation and promote the apoptosis of melanoma cells. In this paper,we will review the research advances in molecular mechanism of curcu-min against melanoma.%黑色素瘤是源于皮肤，粘膜，眼和中枢神经系统色素沉着区域的黑色素细胞的恶性肿瘤，虽然其发病率不高，但恶性程度极高，并且瘤细胞很早就能发生侵袭与转移，从而使患者预后很差。目前黑色素瘤的治疗方式仍以外科手术治疗为主，联合放疗、化疗、中药的综合治疗方案，然而有关黑色素瘤的中医中药治疗方面的研究尚处于起步阶段。最新研究表明，姜科植物属姜黄、郁金、莪术等的活性成分之一姜黄素具有广泛的抗癌、抗炎、抗氧化等药理特性，特别是姜黄素在黑色瘤的预防和治疗中起到不容忽视的作用，姜黄素主要通过抑制黑色素瘤细胞的增殖，促进其凋亡等途径参与黑色素瘤细胞的消亡。本文主要针对姜黄素抗黑色素瘤及其分子机制研究进展作一综述。
展开▼
