CEA、VEGF 标志物与小细胞肺癌预后相关性

摘要

Objective:To evaluate the value of different markers for small cell lung cancer prognosis Methods:Sixty four small cell lung cancer patients and 36 patients with normal diseases were divided into observation group and control group. Immunohistochemistry was used to test LRP enzyme - linked immunosorbent assay ELISA for blood CEA(carcinoembryonic antigen),VEGF(serum vascular endothelial growth factor). Results:Small cell lung cancer patients with benign lung lesions VEGF values were:(290. 7 ± 48. 52)pg/ ml,(123. 5 ± 31. 48)pg/ ml,CEA were:(9. 78 ± 2. 58)ng/ L,(4. 06 ± 0. 84)ng/ L,LRP positive rates were:53. 1% ,5. 6% ,in two groups(P ﹤ 0. 05). VEGF in observed group before and after chemotherapy were:(286. 7 ± 47. 52)pg/ ml,(167. 5 ± 34. 48)pg/ ml,CEA were:(9. 68 ± 2. 48)ng/ L,(5. 16 ± 1. 25)ng/ L,LRP positive rates were:51. 6% ,15. 6% ,there was a significant differ-ence between the two groups(P ﹤ 0. 05). Conclusion:LRP,VEGF and CEA expression levels and other markers in lung cancer tissues was significantly higher than that of normal tissue,can be used to diagnose lung disease,as well as small cell lung cancer prognosis prediction.%目的：探讨不同评价标志物与小细胞肺癌预后相关性。方法：64例小细胞肺癌患者以及同期36例行肺叶切除术的正常患者，分为观察组与对照组。免疫组化 SP 法测定 LRP，酶联免疫吸附法（ELISA）对血液中血清癌胚抗原（CEA）、血清血管内皮生长因子（VEGF）进行检测，同时测定观察组在化疗前后 LRP 阳性率、以及 CEA 与 VEGF 的水平变化情况。结果：小细胞肺癌患者与肺部良性病变的 VEGF 检测值分别为：（290.7±48.52）pg/ ml、（123.5 ± 31.48）pg/ ml，CEA 检测值分别为：（9.78±2.58）ng/ L、（4.06±0.84）ng/ L，LRP 阳性率分别为：53.1％、5.6％，两组比较有显著性差异（P ﹤0.05）。观察组化疗前后的 VEGF 检测值分别为：（286.7±47.52）pg/ ml、（167.5 ± 34.48）pg/ ml，CEA 检测值分别为：（9.68±2.48）ng/ L、（5.16±1.25）ng/ L， LRP 阳性率分别为：51.6％、15.6％，两组比较有显著性差异（P ﹤0.05）。结论：LRP、VEGF 以及 CEA 等标记物在肺癌组织的表达水平显著高于正常组织，可用于对肺癌疾病的诊断以及对小细胞肺癌预后预测。