盐酸羟考酮注射液用于门诊无痛胃肠镜检查及治疗的临床观察

摘要

目的：观察盐酸羟考酮复合丙泊酚用于门诊无痛胃肠镜的麻醉效果。方法：门诊 ASA Ⅰ-Ⅱ级无痛胃肠镜检查及治疗的患者96例，随机分为2组，即丙泊酚复合盐酸羟考酮组（A 组）45例、丙泊酚复合芬太尼组（B 组）51例，记录入室后（T1）、置镜前（T2）、镜子完全置入即刻（T3）、出镜后（T4）4个时间点的 MAP、HR、RR、SPO2及意识恢复时间、呼吸抑制发生率、恶心呕吐发生率、体动例数、检查结束15min 后 Ramsay 评分，丙泊酚用量等。结果：两组在4个时间点 HR 相比均无显著性差异（P >0.05），两组 MAP 在 T2，T3及 T4时间点与 T1时间点相比均具有显著性差异（P <0.05）。B 组的 RR、SPO2在 T3时间点与 T1时间点相比具有显著性差异（P <0.05），与 A 组 T3时间点相比也具有显著性差异（P <0.05）。A 组与 B 组相比意识恢复快，丙泊酚用量少，呼吸抑制发生少，镇静镇痛效果好。结论：丙泊酚复合盐酸羟考酮可安全用于门诊无痛胃肠镜检查及治疗。%Objective:To observe the clinical effect of Propofol combined with oxycodone hydrochloride injection in painless endoscopes. Methods:Ninety six patients in ASA I and II,planned for painless endoscopes,were included in the study. Subjects were randomly divided into two groups:Propofol combined with oxycodone administrated intrave-nousl was group A,and propofol combined with fentanyl infusion was group B. All the subjects were monitored and re-corded MAP,HR,RR and SPO2 after enter into endoscope room(T1),before endoscopes putting(T2),during endo-scopes putting(T3)and after endoscopes taking out(T4). The waking time,respiratory depression occurrence,body movement,Ramsay scale,nausea and vomiting occurrence and dosage of propofol were recorded. Results:MAP de-creased significantly on T2,T3 and T4 compared with that of on T1(P < 0. 05). RR and SPO2 in group B had signifi-cant difference on T3 compared with that on T1,and also had significant difference compared with group A on T3 time point(P < 0. 05). The dose of propofol,waking time and respiratory depression in group A were decreased significantly campared with group B(P < 0. 05). The Ramay scale had no significant difference between the groups(P > 0. 05). There was no patient occurring nausea and vomiting in both groups. Conclusion:Propofol combined with oxycodone hydrochloride injection for painless endoscopes could decrease propofol dosage,avoid respiratory depression and de-curtate waking time.