鄂尔多斯地区晚期肺腺癌患者EGFR敏感基因突变状态与一般临床特征的关系

摘要

目的：分析鄂尔多斯市中心医院晚期肺腺癌患者表皮生长因子受体（epidermal growth factor receptor， EGFR）突变状态与一般临床特征的关系。方法：分析自2012年6月开始收治的Ⅲb -Ⅳ期肺腺癌患者接受EGFR 19、21外显子突变情况与患者一般临床特征、转移部位、治疗情况的关系。结果：选取123例晚期肺腺癌患者纳入分析，46.34%（57/123）的晚期肺腺癌患者接受了 EGFR 19、21外显子检测，EGFR 基因突变率为49.12%（28/57），其中19外显子突变率为39.29%（11/28），21外显子突变率为46.43%（13/28），19、21外显子同时突变率为14.29%（4/28）。EGFR 基因突变状态在患者性别、年龄、吸烟状态、分期、体力评分和转移部位间比较未见显著性差异，19或21外显子突变在患者性别、年龄、吸烟状态、分期、体力评分和转移部位间比较未见显著性差异，根据 EGFR 基因突变状态选择一线治疗模有统计学意义（P <0.05）。结论：鄂尔多斯地区晚期肺腺癌接受 EGFR 敏感基因检测率为46.34%，突变率为49.12%，突变状态在一般临床特征和转移部位间未见显著性差异，根据 EGFR 基因突变状态患者选择一线治疗方式差异有显著意义。%Objective:To explore the clinical features associated with epidermal growth factor receptor(EGFR) gene mutation in advanced lung adenocarcinoma in Erdos Central Hospital. Methods:57of 123 patients with IIIB - IV stage lung adenocarcinoma in our Hospital who received EGFR gene 19,21 exon testing were included. The EGFR gene type was determined by sequencing or amplification refractory mutation system results(ARMS). The factors asso-ciated with EGFR gene mutation were explored by comparing their clinical features,metastasis sites or first - line treatment means. Results:There were 49. 12% EGFR gene mutation among 46. 34% patients who received EGFR gene 19,21 exon testing. There were 39. 29%(11 / 28),46. 43%(13 / 28),14. 29%(4 / 28)gene mutation rate in 19 exon,21exon or 19,21exon mutation. Sex,age,stages,smoking status or ECOG performances hod no statistic signifi-cance between different EGFR gene status group(P > 0. 05). There was no statistic significance about metastasis sites comparision between different EGFR gene status group(P > 0. 05). Wheres first - line treatment regimen was signifi-cantly different decided by EGFR gene mutation condition(P < 0. 05). Conclusion:There were 49. 12% EGFR gene mutation among 46. 34% patients who received EGFR gene 19,21 exon testing. It has no statistic significance involves clinical features and metastasis sites comparision between different EGFR gene status group. Wheres first - line treat-ment regimen was significantly different decided by EGFR gene mutation condition.