45例局限期小细胞肺癌术后预后分析

摘要

目的：对术后的局限期小细胞肺癌（SCLC）可能影响中位总生存期的相关因素进行统计，分析其与预后的关系。方法：统计45例患者的临床资料，包括性别、年龄、肿瘤位置、肿瘤最大径、区域淋巴结转移、术前神经烯醇化酶（NSE）水平、钠离子水平、D 二聚体水平和术后治疗方法等。采用电话形式进行随访，采用Kaplan －Meier 曲线进行单因素生存分析，生存率比较采用 Log －rank 检验；将有统计学意义的变量，纳入COX 比例风险模型进行多因素生存分析。结果：患者中位总生存期是22．0个月。单因素分析显示，术前NSE 水平和术后治疗方法对患者的中位生存期有影响。多因素分析示，术前 NSE 升高、术后未采取辅助治疗是独立危险因素。结论：在行手术治疗的局限期 SCLC 患者中，术前 NSE 升高，术后未采取辅助治疗预后较差。%Objective:To study the related factors influencing the median survival time of limited stage SCLC after surgery,and analyze the relationship between the factors and prognosis.Methods:Clinical data of 45 cases were col-lected,including gender,age,tumor position,maximum tumor diameter,regional lymph node metastasis,NSE,Na +,D-dimer level before surgery and treatment after surgery.Follow up by telephone,and use he Kaplan -Meier curves to conduct univariate survival analysis,while survival rate was compared with Log -rank test.The statistically significant variables were conduct multivariate survival analysis with COX proportional hazard model.Results:The median sur-vival time was 22.0 months.The univariate analysis showed that NSE level before surgery and treatment after surgery were related to survival time.The multivariate analysis showed that raised NSE level before surgery and no treatment after surgery were independent risk factors.Conclusion:Limited stage SCLC patients after surgery with raised NSE level before surgery and without treatment after surgery had poor prognosis.