局部热疗联合同步放化疗治疗Ⅲb 期宫颈癌的近期疗效

摘要

目的：观察局部热疗联合同步放化疗治疗Ⅲb 期宫颈癌的近期临床疗效及不良反应。方法：60例Ⅲb 期宫颈癌患者，随机分为局部热疗结合同步放化疗组（治疗组）和同步放化疗组（对照组）。对照组进行根治性放射治疗，放疗第1天开始行化疗，顺铂40mg／m2，静脉滴注，每周1次，化疗6个周期。试验组：放化疗方法同对照组，于化疗当天行盆腔局部热疗，热疗每次60分钟，每周2次，共12次。于热疗后1h 内行放射治疗。结果：两组外照射结束时局部肿瘤消退情况、近期疗效比较，差异有统计学意义（P ＜0．05）。两组不良反应比较，差异无统计学意义（P ＞0．05）。结论：深部热疗加同步放化疗可以提高患者近期疗效，且无严重的并发症，是Ⅲb 期宫颈癌治疗中的一种安全有效的模式。%Objective:To assess the effect and toxicity of local thermotherapy with chemoradiotherapy in the treat-ment of stage IIIb locally advanced cervical cancer.Methods:All 60 patients with stage IIIb locally advanced cervical cancer were randomly divided into treatment group and control group(30 patients each group).In treatment group,pa-tients received local thermotherapy combined with chemoradiotherapy,whereas patients received chemoradiotherapy a-lone in control group.Results:The overall immediate response rate for treatment group was higher than that for control group(P <0.05).No significant difference was found in toxicity and side effects of the two groups(P >0.05).Con-clusion:Local thermotherapy combined with chemoradiotherapy can be considered as an effective and feasible treat-ment of stage IIIb locally advanced cervical cancer.