脾多肽对胆囊癌化疗患者细胞免疫功能的影响

摘要

Objective:To investigate the effects of lienal polypeptide injection on cellular immunity of gallbladder cancer patients during chemotherapy.Methods:All 30 cases of gallbladder cancer were divided into two groups:thera-py group(chemotherapy +lienal polypeptide)and control group(chemotherapy).The lymphocyte subsets variations were calibrated in each group via flow cytometry.Results:After two cycles of chemotherapy,the percentages of CD4 +T,CD8 + T cells in therapy group were much higher than those in control group (53.73 ±10.24)% vs (31.81 ± 10.19)%,P <0.05;(18.29 ±5.81)% vs (10.23 ±5.96)%,P <0.05.Simultaneously,in therapy group,the per-centage of CD4 +T cell was significantly raised after treatment(43.51 ±7.30)% vs (53.73 ±10.24)%,P <0.05). No difference was observed on percentage of NK cell and side effects of chemotherapy between wo groups (P >0.05).Conclusion:Lienal polypeptide injection can improve immune by promoting the percentages of CD4 +T,CD8 +T cells.%目的：探讨脾多肽对接受胆囊癌辅助化疗患者细胞免疫功能的影响。方法：30例胆囊癌辅助化疗患者分为治疗组（化疗＋脾多肽）和对照组（单纯化疗），采用流式细胞术检测淋巴细胞亚群变化。结果：化疗2周期后，治疗组 CD4＋T、CD8＋ T 细胞占淋巴细胞总数分别为（53．73±10．24）％和（18．29±5．81）％，显著高于同期对照组的（31．81±10．19）％和（10．23±5．96）％（P ＜0．05）。同时，治疗组 CD4＋T 细胞比例较术前的（43．51±7．30）％有明显升高（P ＜0．05）。治疗组和对照组之间 NK 细胞比例差别无统计学意义（P ＞0．05），两组间化疗毒副作用相似（P ＞0．05）。结论：脾多肽可提高胆囊辅助化疗患者外周血 CD4＋T、CD8＋ T 细胞比例，改善免疫功能。