子宫内膜癌的流行病学特点及其转移的危险因素分析

摘要

目的:分析子宫内膜癌的流行病学特点及其转移的危险因素,为合理诊疗与改善预后提供理论依据.方法:回顾性分析310例经术后病理学确诊为子宫内膜癌患者的临床和病理学资料,并对发生转移可能的相关危险因素进行统计分析.结果:子宫内膜癌发病集中在50 ～ 59岁年龄区间,并且该年龄阶段较其它年龄阶段容易发生转移(P＜0.01);子宫内膜癌以内膜样腺癌为主,约占90.97％;其总体转移率为7.41％,Ⅱ型特殊类型内膜癌的转移率明显高于Ⅰ型内膜癌(P＜0.01);内膜样腺癌的分化程度与其转移相关(P＜0.01);浸润深度＜ 1/2组和≥1/2组间的转移率无明显差异(P=0.676).结论:子宫内膜癌好发于围绝经期,年龄、类型和分化程度等可能是其转移的危险因素.%Objective:To analyze the epidemiological characteristics of endometrial cancer and the risk factors of metastasis so as to provide a theoretical basis for rational diagnosis and treatment and improve the prognosis.Methods:A retrospective analysis was made to the clinical and pathological data of 310 patients with endometrial carcinoma diagnosed by pathology after surgery.The possible risk factors of metastasis were analyzed statistically.Results:The peak of incidence of endometrial carcinoma was found in the range of 50 ～ 59 years, and it was more likely to metastasize than other age groups(P ＜ 0.01).The endometrial adenocarcinoma was the most common pathological type, accounting for 90.97％ (P ＜ 0.01).The differentiation of endometrial adenocarcinoma was also correlated with metastasis (P ＜ 0.01).The metastasis of type Ⅱ endometrial carcinoma was significantly higher than that of type Ⅰ endometrial carcinoma(P ＜ 0.01).There was no significant difference in metastasis rate between the two groups of the depth of invasion:＜ 1/2 group and ≥ 1/2 group (P =0.676).Conclusion:The endometrial carcinoma is easy to occur in perimenopausal women and the type and differentiation are risk factors for the metastasis of endometrial carcinoma.