G-CSF预防宫颈癌患者新辅助化疗并行根治术后盆腔感染的临床观察

摘要

Objective:To investigate the effect of granulocyte colony stimulating factor(G-CSF) on the incidence of postoperative pelvic infection in patients with cervical cancer after neoadjuvant chemotherapy and to observe other clinical factors affecting pelvic infection.Methods:The 50 cervical cancer patients with neoadjuvant chemotherapy followed by radical resection were retrospectively analyzed from January 2014 to December 2015 in our hospital.They were divided into two groups.The control group was treated with neoadjuvant chemotherapy, radical operation and postoperative routine anti infection treatments.The observation group was treated with G-CSF on the basis of the control group.The incidence of postoperative pelvic infection was compared between the two groups and the other clinical factors affecting pelvic infection were also analyzed.Results:The incidence of pelvic infection was significantly lower in the observation group than in the control group (16.0％ vs 44.0％, P ＜ 0.05).Other clinical related factors, including age ≥60 years, hemoglobin (Hb) ＜ 90 g/L, neutrophils (ANC) ＜ 1.5 × 109/L patients with postoperative pelvic infection rate was significantly increased(P ＜ 0.05).Conclusion:G-CSF combined with conventional anti-infective agents has a significant effect on reducing the incidence of pelvic infection after neoadjuvant chemotherapy for cervical cancer patients,especially for those with high risk of pelvic infection after surgery patients.%目的:探讨粒细胞集落刺激因子(G-CSF)对新辅助化疗并接受宫颈癌根治术患者术后盆腔感染发生率的影响,并观察其它影响盆腔感染的临床相关因素.方法:回顾性分析2014年1月至2015年12月我院妇产科收治的50例Ⅰb期和Ⅱ期新辅助化疗并行宫颈癌根治术患者,根据术后是否采用G-CSF治疗分为对照组和观察组两组.对照组采用新辅助化疗并手术,术后常规抗感染治疗,观察组在前组基础上予以G-CSF进行治疗.比较两组患者术后盆腔感染发生率,并分析影响盆腔感染的因素.结果:采用G-CSF进行治疗的观察组术后患者盆腔感染率明显低于对照组患者,发生率分别为16.0％和44.0％ (P ＜0.05).其它临床相关因素,包括年龄≥60岁、血红蛋白(Hb) ＜90 g/L、中性粒细胞计数(ANC) ＜1.5×109/L的患者术后盆腔感染率明显增高(P＜0.05).结论:在常规抗感染基础上联合应用G-CSF对于新辅助化疗并行宫颈癌根治术患者术后降低盆腔感染发生率具有明显的效果,尤其是对于那些术后具有高风险盆腔感染发生率的患者值得临床进一步验证和推广.