血清CEA、SCC和CYFRA21-1在食管癌放、化疗前后的变化

摘要

Objective:To study the changes of serum carcinoembryonic antigen (CEA),squamous cell carcinoma antigen (SCC)and the cell keratin protein fragment (CYFRA21-1)in patients with esophageal cancer pre&post ra-dio-chemotherapy.Methods:Totally data of 100 patients with esophageal cancer underwent radio-chemotherapywere selected as experimental group,another 26 physical volunteers as control.The serum content of CEA,SCCa and YFRA21-1 were detected by using ELISA before and after radio-chemotherapy of the patients.The level of the marks related to tumor infiltrating degree,TNM stage was analyzed statistically.Results:The levels of serum CEA, SCC,CYFRA21-1 were significantly higher than that of control group before treatment (P< 0.05),but they de-creased after treatment significantly (P< 0.05).However there was no significant difference between the experimental and control group (P > 0.05).It was found that the levels of CEA,SCC,CYFRA21-1 were significantly related to TNM stage,tumor infiltration (T 4 highest)in patients with esophageal cancer (P< 0.05).Conclusion:The level of serum CEA,SCC,CYFRA21-1 is respectively and significantly related with TNM stage,tumor infiltration and redio-chemotherapy in patients with esophageal cancer.It might be helpful to make personalized treatment plane and to eval-uate its effect for patients with esophageal cancer.%目的:研究食管癌放、化疗前后血清癌胚抗原(CEA)、鳞状上皮细胞癌相关抗原(SCC)和细胞角化素蛋白片段(CYFRA21-1)的变化.方法:选2014年至2016年接受放化疗的食管癌100例作为研究组,健康体检者26例为对照组.采用酶联免疫吸附法(ELISA)检测患者血清治疗前、后CEA、SCC、CYFRA21-1水平,分析治疗前后的变化,以及与病理类型、肿瘤浸润度、TNM分期的关系.结果:治疗前研究组血清CEA、SCC、CYFRA21-1水平均明显高于对照组(P<0.05),治疗后研究组均有明显下降(P<0.05);与不同病理分期、肿瘤浸润深度、TNM分期差异明显,其中Ⅲ期、T 4期最高(P<0.05).但与对照组比较无差异(P>0.05).结论:血清CEA、SCC、CYFRA21-1在不同病理分期、TNM分期及放化疗前后的食管癌患者血清含量不同,对于食管癌患者制定个性化治疗方案以及观察疗效有重要意义.