高危型人乳头瘤状病毒感染与湖北十堰食管鳞癌发生的关系研究

摘要

目的:检测高危型人乳头瘤病毒(human papillomavirus,HPV)在十堰地区食管鳞癌(esophageal squa-mous cell carcinoma,ESCC)组织中的感染率,分析其相关性.方法:收集十堰地区87例食管鳞癌组织和50例对照组食管组织,实时荧光定量PCR法检测组织中HPV16感染率.结果:食管鳞癌组织和对照组食管组织中HPV16的检出率分别为57.5%和36.0%,食管鳞癌组织中HPV16感染率显著高于对照组(P=0.016<0.05).分析食管鳞癌患者年龄、性别、病理分级、大体分型、浸润深度、淋巴结侵犯以及TNM分期与HPV16感染的关系,差异均无统计学意义.HPV16感染与食管鳞癌患者临床特征未见显著相关性.结论:HPV16感染可能是十堰地区食管鳞癌发生的因素之一,针对高危型HPV感染的防治对于该地区食管鳞癌的发生具有重要意义.%Objective:To detect the infection rate of high-risk human papillomavirus (HPV)in the tissues of e-sophageal squamous cell carcinoma (ESCC)in Shiyan and analyse their relationship.Methods:To collect 87 ESCC tissues and 50 controls esophageal tissues,and detect the HPV16 infection rate in tissues by real-time PCR.Re-sults:The infection of HPV16 in ESCC tissues and controls were 57.5% and 36.0%,respectively.The HPV16 infec-tion rate in ESCC tissues was significantly higher than in controls (P = 0.016< 0.05).There were no significant differences between the HPV16 infection rate and the age,gender,tumor differentiation,general classification,infiltra-tion depth,lymph node status and TNM staging.No significant difference could be seen between the HPV16 infection and clinical characteristics of ESCC patients.Conclusion:HPV16 infection may be one of the pathogenic factors of ESCC in Shiyan,which indicates the infection of high-risk HPV could be helpful for the prevention of ESCC in Shiyan.