前列腺癌癌症相关性乏力的临床研究

摘要

Objective:To evaluate the relationship between cancer-related fatigue symptoms(CRFS)and clinical characteristics of prostate cancer patients(PCP).Methods:147 patients diagnosed as prostate cancer from December 2006 to December 2016 were retrospectively analyzed.Brief fatigue scale was used to evaluate the relationship between CRFS and clinical characteristic.Results:The incidence of CRFS was 91.8%.The fatigue index(FI)of PCP with diabetes was highest,there was significant difference among them(P<0.05).FI was positively correlated to ECOG scores and education level,the difference had statistically significant(P<0.05).The higher of PSA level,the higher of FI,there was significant difference among them(P<0.05).The FI of PCP with G3,G4 was higher than G1,G2,however,there was no significant difference among them(P>0.05).The FI of Gleason≤6 was lower than the other two groups,with significat difference(P<0.05).T stage and TNM stage were positively correlated to FI(P<0.05).The results was same to risk factors.Conclusion:CRFS is related to the history of basic diseases,ECOG,education level,PSA level,Gleason score and TNM stage.%目的:评价癌症相关性乏力(cancer-related fatigue symptoms,CRFS)与前列腺癌患者临床病理特征的相关性.方法:回顾性分析2006年12月至2016年12月147例初治前列腺癌患者临床资料,采用简明疲劳量表评估乏力指数与临床资料的相关性.结果:全组147例前列腺癌患者中,乏力总发生率为91.8%(135例).无基础疾病史组的乏力指数明显低于基础疾病史组,有糖尿病病史的乏力指数最高,各组比较有统计学差异(P<0.05);乏力指数与ECOG评分、文化程度水平呈正相关,差异有统计学意义(P<0.05);PSA水平增高,乏力指数明显升高,各组比较差异有统计学意义(P<0.05);病理分级G3、G4乏力指数高于G1、G2,但组间差别无统计学意义(P>0.05);Gleason评分≤6组的乏力指数明显低于其他两组,各组比较差异有统计学意义(P<0.05);T分期越高,乏力指数越高,各个分期乏力指数比较有统计学意义(P<0.05);乏力指数在N分期中无明显差别(P>0.05);TNM分期、危险因素等级与乏力指数呈正相关(P<0.05).结论:前列腺癌CRFS与基础疾病史、ECOG、文化程度、PSA水平、Gleason评分及TNM分期密切相关.