基因单核苷酸多态性与宫颈癌易感性研究进展

摘要

高危型人乳头瘤病毒的持续感染是宫颈癌发生过程中的必要环境因素,并已得到公认.而HPV感染的最终结局受宿主遗传易感性影响.肿瘤遗传易感性由个体基因组上单个核苷酸变异形成的单核苷酸多态性(SNP)而决定.SNP是人类可遗传的变异中最常见的一种基因,在人类基因组中广泛存在,分布广,适于快速、规模化筛查.本文就基因单核苷酸多态性与宫颈癌易感性的研究进展做一综述.%Cervical cancer is one of the most common gynecologic malignant tumor.High-risk human papillomavirus infection is the necessary environmental factor in the development of cervical carcinoma,while host genetic predisposition to the disease impact the outcome of infection.Genetic susceptibility refers to the potential susceptibility to diseases at the genetic level,can be inspired under certain conditions.Single-nucleotide polymorphisms is the new class of genetic marker,which is widely used to search cancer genes.This review will focus on the advances in the research of single-nucleotide polymorphisms in genes associated with cervical cancer in recent years.