生长分化因子15在上皮性卵巢癌中的表达及临床意义

摘要

Objective:To study the expression of growth of differentiation factor 15 (GDF15) in epithelial ovarian cancer (EOC) and its association with clinical pathological factors.To observe the level of GDF15 in the serum of patients with EOC.Methods:Expression of GDF15 level was detected in specimens of 92 human EOC patients by immunohistochemistry and enzyme-linked immunosorbent assay.Results:The intensity of GDF15 in EOC tissue was significantly higher than that of normal ovarian tissue.It was also significantly correlated with FIGO stage,histologic differentiation,ascites and lymphatic metastasis.The serum GDF15 level (1 307.72±352.99)pg/ml was significantly higher in the EOC group than that in the control group (405.88±75.67)pg/ml (P<0.01).Conclusion:The expression level of GDF15 was closely related to the development EOC.Thus,maybe GDF15 is meaningful for diagnosis and predicting prognosis in patients with EOC.%目的:探讨生长分化因子15(growth differentiation factor 15,GDF15)在上皮性卵巢癌组织中的表达及其与临床病理因素的相关性.同时探讨上皮性卵巢癌患者血清GDF15水平及其对诊断的意义.方法:应用免疫组织化学、酶联免疫吸附试验检测92例上皮性卵巢癌患者组织及血清中GDF15表达水平.结果:上皮性卵巢癌患者组织GDF15的表达强度显著高于正常卵巢组织,且与患者手术分期、病理分级、有无腹水及淋巴结转移相关.上皮性卵巢癌患者血清GDF15水平(1 307.72±352.99)pg/ml显著高于正常对照组(405.88±75.67)pg/ml(P<0.05).结论:GDF15表达水平与上皮性卵巢癌发生发展密切相关,对于卵巢癌患者诊断及预后预测具有一定的指导意义.