肺癌患者与健康人群血常规指标比较

摘要

目的:对未经过任何治疗的初诊肺癌患者与健康人群血常规中白细胞计数、中性粒细胞计数、淋巴细胞计数和中性粒细胞-淋巴细胞比率(NLR)进行比较,探讨各项指标在肿瘤发生发展中的意义.方法:收集2013年1月至2013年12月期间,于我院接受手术治疗并经病理诊断确诊的206名肺癌患者的初次血常规检查结果及病理资料,与同年在我院体检中心接受体检的健康人群血常规结果,以患者年龄和性别作为配比因素,按1:1比例配对选择对照组.对两组研究对象血常规结果中的白细胞计数、中性粒细胞计数、淋巴细胞计数以及通过计算得到的中性粒细胞与淋巴细胞比率进行配对t检验分析.结果:肺癌组白细胞计数、中性粒细胞计数及NLR值均高于健康对照组,结果分别为(6.88±1.63)×109/L vs (6.34±1.38)×109/L;(4.65 ±1.47)×109/L vs (3.50 ±0.99)×109/L;2.98±1.98 vs l.65 ±0.64.而肺癌组淋巴细胞计数明显低于健康对照组[(1.78±0.57)×109/L vs (2.27±0.66)×109/L].按年龄分层分析发现这些血常规指标差异与年龄无关.随着肿瘤TNM分期进展,白细胞、中性粒细胞及NLR值升高,而淋巴细胞计数下降.并且较无远处转移者相比,有远处转移者肺癌NLR值升高.结论:肺癌的发生与免疫状态低下和炎症反应有关,NLR可能成为肺癌的预后指标.%Objective:To compare the differences of leukocyte,neutrophil,lymphocyte and the neutrophil-to-lymphocyte ratio (NLR) between the healthy people and patients with lung cancer,to explore the relationship between indicators in tumorigenesis.Methods:A total of 206 patients who underwent complete resection for tung cancer from January 2013 to December 2013,were compared with the results of the healthy people.Based on age and gender,lung cancer patients and healthy people were matched according to 1:1.T test was used for two sets of data analysis.P ＜ 0.05 was statistically significant.Results:Compared with the healthy people,the leukocyte,neutrophil count and NLR were raised in the lung caner patients [(6.88 ± 1.63) × 109/L vs (6.34 ± 1.38) × 109/L,(4.65 ± 1.47) × 109/L vs (3.50 ± 0.99) × 109/L,2.98 ± 1.98 vs 1.65 ± 0.64 respectively].However,the lymphocyte count was decreased [(1.78 ± 0.57) × 109/L vs (2.27 ± 0.66) × 109/L].These differences were independent of age.The increase of leukocyte,neutrophil count and NLR were associated with the tumor stage.Conclusion:Lung cancer relates to the poor immune and inflammatory response.NLR might be indicators of early diagnosis of lung cancer.