腹水和血清中HE4对卵巢癌的诊断价值

摘要

目的：探讨血清、腹水中人附睾蛋白4（HE4）在卵巢癌诊断中的应用价值。方法：酶联免疫法测定38例有腹水卵巢癌患者和30例良性腹水患者的血清和腹水中HE4含量。分析血清和腹水中HE4在卵巢癌诊断中的意义。结果：卵巢癌组腹水HE4水平明显高于血清HE4水平，差异有统计学意义（P＜0．05）；卵巢癌组血清HE4水平明显高于良性腹水组血清HE4，差异有统计学意义（P＜0．05），卵巢癌组腹水HE4水平明显高于良性腹水组腹水HE4，差异有统计学意义（P＜0．05）。良性腹水患者血清、腹水HE4水平无统计学意义（P＞0．05）。腹水HE4敏感性显著高于血清的HE4敏感性。结论：腹水HE4水平是卵巢癌诊断的重要指标之一。腹水HE4水平高于血清应高度怀疑卵巢癌。对有腹水的患者通过常规检查腹水HE4水平联合血清HE4检测，可提高卵巢癌诊断率。%Objective:To study the diagnosis value of human epididymis protein 4 (HE4)level in serum and asci-tes of ovarian cancer patients.Methods:HE4 in serum and ascites of 38 ovarian cancer patients and 30 ascites benign patients were measured by euzymelinked immunosorbent assay(ELISA)and the significance of the HE4 levels were analyzed.Results:HE4 levels of cases of ovarian cancer in ascites were significantly higher than HE4 levels of ovarian cancer in serum(P<0.05).HE4 levels of ovarian cancer in serum were significantly higher than HE4 levels of be-nign ascites in serum(P<0.05).HE4 levels of ovarian cancer in ascites were significantly higher than HE4 levels of benign ascites in ascites(P<0.05 ).HE4 levels of benign ascites in ascites were not significantly higher than HE4 levels of benign ascites in serum(P>0.05).The sensitivity of HE4 ascites of ovarian cancer patients was significant-ly higher HE4 in serumof ovarian cancer patients.Conclusion:HE4 levels is one of important index of the diagnosis of ovarian cancer.If the level of HE4 in ascites was higher than that of serum,it was highly suspected of ovarian cancer. The HE4 level of ascites combined with serum HE4 routinely detection in patients can improve the diagnosis of ovari-an cancer.