分段式放疗对放射性直肠炎预防作用的实验研究

摘要

Objective:To investigate the preventable effects of the split course radiotherapy on radiation proctopa-thy.Methods:Forty-five SD rats were randomly divided into nine groups.Group A:Nomal control group.Group B to group I:The rats were treated pelvic cavity with radiotherapy,DT 44Gy/(22f·30d),5f/w,6 weeks after treatment re-ceived a RT boost,DT 46Gy/(23f·31d),5f/w.Rectal mucosal changes were observed in d0,d30,d72,d86,d103,d143, d145 ,d159 ,d193 and d283 respectively under biopsy microscope.Results:Before,during and after radiotherapy,we ob-served the rectal mucosal inflammatory changes,repair,reinjury,repair,and no Ⅲ-Ⅳ grade radiation enteritis oc-curred.Conclusion:Given the radical dose,the split course radiotherapy can prevent severe proctitis,has potential clinical application value.%目的：探讨分段式放疗对放射性直肠炎的预防作用。方法：45只SD大鼠随机分为空白对照组及腹盆腔放疗组。放疗组放疗方案为DT 44Gy／（22f·30d），5f／w，间隔6周，再DT 46Gy／（23f·31d），5f／w放疗。分别在d0、d30、d72、d86、d103、d143、d145、d159、d193及 d283于显微镜下观察直肠黏膜的变化。结果：在放疗前、中、后显微镜下可以观察到直肠黏膜炎性改变，修复，再次损伤，修复，未见Ⅲ－Ⅳ级放射肠炎发生。结论：给予根治剂量、分段式放疗可预防严重放射性直肠炎的发生，有潜在的临床应用价值。