受体O型蛋白酪氨酸磷酸酶与表皮生长因子受体2在乳腺癌中表达的相关性

摘要

目的:分析受体0型蛋白酪氨酸磷酸酶(PTPRO)与表皮生长因子受体2(HER2)在乳腺癌中的表达及其临床意义.方法:采用免疫组织化学EnVision法检测50例原发乳腺癌组织中PTPRO与HER2的表达状态并结合临床病理资料进行统计分析.结果:乳腺癌组织中PTPRO阳性表达率40.0％(20/50),PTPRO表达缺失同淋巴结转移和孕激素受体表达相关(P ＜0.05);HER2阳性表达率68％ (34/50),同肿瘤大小、淋巴结转移和孕激素受体表达相关(P＜0.05).PTPRO与HER2表达呈负相关(P =0.026).结论:PTPRO与HER2表达同乳腺癌临床病理特征密切相关,联合检测二者具有潜在的临床诊断意义.%Objective:To examine the expression status of protein tyrosine phosphatase receptor O (PTPRO),human epidermal growth factor receptor 2 (HER2) and their potential clinical significance human breast cancer.Methods:Immuno-expression of PTPRO and HER2 were detected by immunohistochemistry (IHC) analysis in 50 primary breast cancer tissues.The relationship of the expression between PTPRO and HER2 with clinical pathological parameters were analyzed.Results:PTPRO and HER2 expression were observed in 40.0％ (20/50)and 68％ (34/50) of the primary breast cancer tissues,respectively.Loss of PTPRO expression was correlated with lymph node metastasis and progesterone receptor (PR) expression.HER2 expression was correlated with tumor size,lymph node metastasis and PR expression.Additionally,a negative correlation was found between PTPRO and HER2 expression.Conclusion:PTPRO and HER2 expression were signicantly associated with the clinicopathologic features in breast cancer.