原发性肝癌合并2型糖尿病患者临床病理特点的比较性研究

摘要

目的:对比分析原发性肝癌合并2型糖尿病患者的临床病理特点,为临床治疗提供一定治疗依据.方法:回顾性分析手术切除治疗且经病理确诊的原发性肝癌患者资料,比较合并2型糖尿病(T2DM组)与无合并2型糖尿病患者(无T2DM组)的临床病理特点,分析患者的性别、年龄、教育程度、吸烟、饮酒、BMI、Child-Pugh分级、实验室检查、病理TNM分期等的异同.结果:T2DM组的男性患者比例高于无T2DM组.T2DM组患者的年龄为(58.07 ±9.77)岁,高于无T2DM组(51.76±11.22)岁,P＜0.001.入院时的收缩压、舒张压、BMI、伴有慢性病高血压患者也高于无T2DM组(P＜0.05).两组间肝癌都以中分化肝细胞癌为主,但所占比例有统计学差异,T2DM组高分化所占比例高于无T2DM组.而在肝硬化、乙肝、AFP值中却是无T2DM组高于T2DM组.吸烟、饮酒、教育程度、肝功实验室检查、Child-Pugh分级、TNM分期等在两组间无明显统计学意义.结论:2型糖尿病可能加大肝癌的发生率,尤其是老年男性患者,建议肝癌患者应注意筛查2型糖尿病或糖尿病前期,关注肝癌合并2型糖尿病患者的治疗.%Objective:To analye the clinicopathological features of primary liver cancer with type 2 diabetes mellitus,to provide evidence for clinical treatment.Methods:Primary data about liver cancer patients which had surgical resection and pathological diagnosis were retrospectiely analysed,compared with type 2 diabetes mellitus group (T2DM group) and without type 2 diabetes mellitus group (without T2DM group) in patients with clinically pathological features.Extract the patient's information,such as gender,age,education level,systolic blood pressure,diastolic blood pressure,smoking,drinking,BMI,Child-Pugh classification,liver laboratory tests,pathological TNM staging and so on.Results:The age in T2DM group [(58.07 ± 9.77) years] was significant different with without T2DM group[(51.76-± 11.22) years,P ＜0.001].There was also significant difference between the patients with T2DM group and without T2DM group in gender (P =0.003),BMI (P ＜ 0.001),hypertension (P ＜ 0.001),liver cirrhosis (P ＜ 0.001),hepatitis B (P ＜ 0.001) and AFP (P =0.003).Hepatocellular carcinoma accounted for the majority in the two groups,but there were significant differences in the proportion.The high differentiated proportion in T2DM group was higher than those without T2DM group.There was no significant difference between the two groups in smoking,drinking,education level,liver laboratory tests,Child-Pugh and TNM staging.Conclusion:Diabetes has a high incidence in liver cancer patients and is more comnon with elder male patients.Patients with liver cancer should pay attention to screening for type 2 diabetes or prediabetes and more concerns should be put onto type 2 diabetic mellitus patients with liver cancer.