卵巢癌基因1在人类恶性肿瘤中的研究进展

摘要

卵巢癌基因1(ovarian cancer gene 1,OVCA1)位于人染色体17p13.3,在哺乳动物细胞中高度保守,与酵母菌的DPH2具有同源性.在哺乳动物细胞中,OVCA1参与维持翻译的保真性、调控细胞周期及胚胎发育等多种生物学过程.OVCA1在卵巢癌、乳腺癌和宮颈癌等多种肿瘤中存在高频率的杂合性缺失和突变,作为候选肿瘤抑制基因在肿瘤发生发展中发挥重要作用.本文就OVCA1基因的生物学功能及与不同类型肿瘤关系的研究进展做一综述.%Ovarian cancer gene 1 (OVCA1) is located on the 17p13.3 of human chromosome,and it is highly conserved in mammals.At the same time,the gene has the identity and similarity with the yeast DPH2.OVCA1 plays an important role in maintaining the fidelity of translation,regulating cell cycle and regulating embryonic development and so on.As a novel candidate tumor suppressor gene,there is a high frequency of LOH (loss of heterozygosity) and mutation of OVCA1 in a variety of tumors such as ovarian,breastand cervical cancers.Therefore the gene might play an important role in tumorigenesis and development of tumors.In this review,we would focus on the biological function of OVCA1 and its association with tumors.