预防性 HPV 疫苗的临床应用进展及思考

摘要

宫颈癌是女性生殖系统最常见的恶性肿瘤，并且高危型人乳头瘤病毒（human papillomavirus， HPV）持续感染与宫颈癌的密切关系已经得到流行病学及临床研究证实。因此，HPV 疫苗在预防 HPV 持续感染及宫颈相关病变等方面备受瞩目。本文对目前美国 FDA 批准上市的3种预防性疫苗的临床应用进展进行综述，同时列举出一些尚存在争议的问题，旨在引起人们的重视及共同思考。%Cervical cancer is the most common cancer in female genitourinary system.The close relationship between high -risk human papillomavirus(HPV)persistent infection and cervical cancer had been confirmed by epidemiology studies.Hence,HPV vaccine has attracted tremendous attention on preventing HPV infection and cervical lesions. Our review focusd on the three types of HPV prophylactic vaccines which have been approved for marketing by FDA. We also list some controversies which could draw more attention and thought -provoking.