Aspp2与肿瘤相关性的研究

摘要

p53凋亡刺激蛋白2（apoptosis stimulating of p532，Aspp2）是 p53凋亡刺激蛋白家族（apoptosis stimulating of p53，Aspp）中的重要成员。作为一个重要的抑癌基因，Aspp2常与 p53结合，对肿瘤产生抑制作用。此外，基因启动的甲基化修饰、部分转录因子的激活作用等也能调节 Aspp2的表达，从而对多种肿瘤产生不同程度的影响。本文对 Aspp2基因与多种肿瘤相关性的研究作一综述。%Apoptosis stimulating of p53 2(Aspp2)is a member of the apoptosis stimulating of p53 family.When it was combined with p53,it had an inhibitory effect on tumors.Besides,methylation modification and activation of some transcription factors can also affect the expression of Aspp2.In this paper,a review of the effects of Aspp2 gene on tumors was made.