乳腺癌骨转移机制与靶向治疗进展

摘要

Bone metastasis are common symptoms of advanced breast cancer,breast cancer cells via local infiltration, invading into lymphatic and /or blood vessels,travelling in the circulation to the bone,extravasation from lymphatic and /or blood vessels,settling and proliferating in the bone and then caused osteolytic bone lesions.The initiation and development of bone metastasis with breast cancer depends on the interaction between breast cancer cells and the bone microenvironment,finally formed bone structural damage and dysfunction.This article describes the mechanism of bone metastasis of breast cancer at the molecular level,and summaries the clinical application of targeted drugs for the bone metastasis.%乳腺癌骨转移是晚期乳腺癌常见的症状，乳腺癌细胞通过局部浸润、渗入血管和或淋巴管、随循环系统转移到骨、移出血管和或淋巴管、在骨定居并增殖引起溶骨性骨损伤。乳腺癌骨转移的发生发展取决于乳腺癌细胞与骨局部微环境之间相互作用，最后形成骨的结构破坏及功能受损。本文主要从分子水平阐述乳腺癌骨转移机制，并且综述针对乳腺癌骨转移关键靶点的抗骨转移药物的临床应用。