83例结直肠癌体外药物敏感性及临床病理参数相关性

摘要

目的：通过结直肠癌体外药物敏感性实验，分析临床病理因素与7种化疗药物体外药敏结果相关性，从而为临床选择化疗药物提供理论依据。方法：收集100例新鲜人结直肠癌标本，均经病理证实为癌。采用三维微组织块培养法（ HDRA）比较7种化疗药物的体外敏感性。成功完成83例，同时评价体外药敏结果与临床病理参数之间的相关性。结果：7种化疗药物的体外敏感性结果依次为：5-FU 43.93%、奥沙利铂52.00%、伊立替康25.39%、培美曲塞33.13%、雷替曲塞32.01%、多西紫杉醇16.73%、吉西他滨23.14%。体外药敏结果与患者年龄、性别、部位、淋巴结转移、分期没有明显相关性，而与分化程度呈负相关。结论：体外药敏实验对临床用药具有一定指导意义，结直肠癌分化水平与化疗药物体外药敏结果具有一定相关性。%Objective:To investigate the chemosensitivity of freshly-removed colorectal tumor specimens. Meth-ods:We collected 83 freshly-removed colorectal tumor specimens,chemosensitivities to seven chemotherapy drugs were detected by HDRA,and to explore the relationship between clinilcopathological features and chemosensitivities. Results:The inhibitions of seven drugs were as follows:5-FU 43. 93%,Oxaliplatin 52. 00%,Irinotecan 25. 39%, Pemetrexed 33. 13%,Raltitrexed 32. 01%,Docetaxel 16. 73%,Gemcitabine 23. 14%. There were no significant asso-ciations between age,gender,site,lymphonode metastasis,stage and chemosensitivity. However,there was significant relationship between grade and chemosensitivity. Conclusion:Chemotherapy under the guidance of in vitro chemosen-sitivity may be a good choice in colorectal cancer. Grade can be a predictor in chemosensitivity in colorectal cancer.