miRNA调控EMT影响结直肠癌侵袭转移的研究进展

摘要

Colorectal cancer is one of the most common malignancies worldwide,recurrence and metastasis are the major reasons causing deaths. Epithelial-mesenchymal transition( EMT)refers to the biological processes that epithe-lial cells transform to mesenchymal phenotype cells,which plays an important role in in situ infiltration and distant metastasis of many types of tumor. MicroRNA( miRNA)is a class of non-coding small endogenous RNA,which can regulate gene expression at the post-transcriptional level. Increasing researches demonstrate that miRNA can involve in the regulation of EMT process,thereby affecting the invasion and metastasis of tumors.%结直肠癌是世界范围内最常见的恶性肿瘤之一，其复发和转移是导致病人死亡的重要原因。上皮-间质转化（ EMT）是指上皮细胞转化为具有间质表型细胞的生物学过程，在多种类型肿瘤的原位浸润和远处转移扮演重要角色。MicroRNA（ miRNA）是一类内源性非编码小RNA，在转录后水平调控基因的表达，越来越多的研究发现miRNA可参与调控EMT的过程，从而影响肿瘤的侵袭及转移。本文就与结直肠癌EMT密切相关的miRNA的研究进展做一综述。