改良GC方案与传统GC方案治疗尿路上皮癌疗效及毒副反应的对比

摘要

Objective:To compare the efficacy and toxicity of modified GC regimen and conventional GC regimen in chemotherapy for patients with urothelial carcinoma.Methods:In this study,70 cases of urothelial carcinoma were selected from December 2008 to June 2016,who were admitted by the Department of Urology,Beijing Jishuitan Hospi-tal.38 patients underwent modified GC chemotherapy and 32 patients received conventional 3-week GC chemothera-py.After two cycles of chemotherapy,the efficacy and toxicities of chemotherapy were evaluated.Results:The total ef-fective rate was 50.0%(19/38)and 53.1%(17/32)in the modified GC regimen and the conventional regimen group.No statistically significant difference was seen between the two groups(P>0.05).The incidence of gradeⅢ-Ⅳ haematological toxicity was 15.8%(6/38)and 37.5%(12/32),respectively,in the modified GC group and the conventional GC group,and the difference was statistically significant(P<0.05).There was no significant difference between the two groups in terms of the other side effects(P>0.05).Conclusion:Modified GC regimens can be used as alternatives to traditional GC regimens in chemotherapy for patients with urothelial carcinoma.%目的:比较改良GC方案和传统GC方案在尿路上皮癌化疗中的疗效和毒副反应.方法:本研究选取自2008年12月至2016年6月北京积水潭医院泌尿外科收治的尿路上皮癌患者共70例.38例采用改良GC化疗方案,32例采用传统三周GC化疗方案.所有患者在完成2个周期的化疗后,进行疗效及毒副反应评价.结果:改良GC方案和传统GC方案化疗组患者治疗后总有效率分别为50.0%(19/38)和53.1%(17/32),两组之间的差异无统计学意义(P>0.05);改良GC方案化疗组和传统GC方案化疗组中患者发生Ⅲ-Ⅳ度骨髓抑制的比率分别中15.8%(6/38)和37.5%(12/32),差异有统计学意义(P<0.05);其余毒副反应相比差异均无统计学意义(P>0.05).结论:在尿路上皮癌患者的化疗中,改良GC化疗方案可以作为传统GC方案的替代在临床中尝试.