过表达HIF-1α和VEGF蛋白与垂体腺瘤侵袭行为的关系

摘要

Objective:To explore the protein expression of hypoxia-inducible fator-1α and VEGF in pituitary adenoma and their relation with invasion of pituitary adenoma.Methods:Among the collected data of 32 cases of pitu-itary adenoma,20 cases were invasive pituitary adenoma and 12 cases were non-invasive pituitary adenoma.Immuno-chemistry staining was used to determine the protein expression of HIF-1α and VEGF.Protein expression of invasive pituitary adenoma group and non -invasive pituitary adenoma group and the protein expression of HIF -1α and VEGF in pituitary adenomas with different size were analyzed and compared.Results:The positive rate of protein ex-pression of HIF-1α and VEGF in invasive pituitary adenomas group showed statistically significant compared with that of the non-invasive pituitary adenomas group(P<0.05).The positive rate of protein expression of HIF-1α and VEGF in pituitary adenomas with diameter larger than thirty mm showed statistically significant compared with those with diameters between ten mm to thirty mm(P<0.05).Conclusion:There were overexpression of HIF-1α and VEGF in pituitary adenomas,and these studies that the activation of HIF-1α and VEGF protein can increase the invasion of pituitary adenomas.%目的:探讨缺氧诱导因子-1α(HIF-1α)和血管内皮生长因子(VEGF)在垂体腺瘤中的表达及与垂体腺瘤侵袭性的关系.方法:收集的32例垂体腺瘤标本中侵袭性垂体腺瘤20例,非侵袭性垂体腺瘤12例,应用免疫组化染色检测HIF-1α和VEGF蛋白的表达.并对侵袭组与非侵袭组的HIF-1α和VEGF蛋白表达及不同大小肿瘤HIF-1α和VEGF蛋白表达进行分析比较.结果:非侵袭组垂体腺瘤中HIF-1α和VEGF蛋白表达阳性率与侵袭组比较,差异有统计学意义(P<0.05);垂体腺瘤直径大于30 mm者 HIF -1α和VEGF蛋白表达阳性率与直径10~30 mm者比较,差异有统计学意义(P<0.05).结论:HIF-1α和VEGF蛋白在侵袭性垂体腺瘤中的表达明显增加,并且与垂体腺瘤侵袭行为密切相关.