多发性骨髓瘤患者中性粒细胞与淋巴细胞比值与预后相关性分析

摘要

目的:研究外周血中中性粒细胞与淋巴细胞比值(NLR)在多发性骨髓瘤(MM)患者预后中的价值.方法:回顾性分析88例初诊MM患者的临床资料,将MM患者分为高NLR组与低NLR组,分析两组患者在血红蛋白(Hb)、血清钙离子(Ca)、血清β2微球蛋白(β2-MG)、血清白蛋白(ALB)、血清肌酐(Cr)、国际分期标准(ISS)和总体生存期(OS)方面的差异.结果:与低NLR组相比,高NLR组血清β2 -MG偏高、Cr偏高、Ca偏高、ISS分期偏晚、OS短,差异均有统计学意义(P<0.05).结论:MM患者外周血中NLR升高提示预后不良,NLR与血清β2-MG、Cr等指标相结合,对于MM患者的预后评估有重要的意义.%Objective:To study the value of neutrophil to lymphocyte ratio(NLR)in the prognosis of patients with multiple myeloma(MM).Methods:The clinical data of 88 newly diagnosed MM patients were analyzed retrospective-ly.MM patients were divided into high NLR group and low NLR group.The hemoglobin(Hb),serum calcium(Ca), serum β2 microglobulin,albumin(ALB),serum creatinine(Cr),international staging criteria(ISS)and overall surviv-al(OS)were analyzed.Results:There were statistically significant differences in the expression of β2-MG,Ca and Cr between high NLR group and low NLR group(P<0.05).There were also statistically significant differences in the ISS,over survival between high NLR group and low NLR group(P<0.05).Conclusion:NLR combination with β2-MG,Cr and Ca can provide important value to evaluate the prognosis of MM patients.