PI3K/Akt信号通路与肿瘤血管新生的研究进展

摘要

PI3K/Akt信号通路在多种细胞中活化,参与细胞的增殖、分化、凋亡、血管新生等病理、生理过程.血管的生成需要PI3K/Akt信号通路的激活,PI3K/Akt活化后可以广泛诱导鸡胚尿囊膜血管的生成.PI3K/Akt信号通路与其下游信号分子mTOR及多种促血管新生因子,如VEGF、HIF等相互作用,从而促进肿瘤血管新生.PI3K/Akt信号通路抑制剂能够抑制其血管新生作用,因此靶向PI3K/Akt信号通路为恶性肿瘤靶向治疗提供了新方法.%PI3K/Akt signaling pathway is activated in variety of cells.It is involved in the pathological and physio-logical processes of cell proliferation,differentiation,apoptosis and angiogenesis.Angiogenesis is required for activation of the PI3K/Akt signaling pathway,and activation of PI3K/Akt induces extensive angiogenesis in chick embryo chori-oallantoic membranes.The PI3K/Akt signaling pathway interacts with its downstream signaling molecule mTOR and a variety of angiogenic factors such as VEGF and HIF,then enhancing tumor angiogenesis.Inhibitors of PI3K/Akt sig-naling pathway can inhibit their angiogenesis,so targeting PI3K/Akt signaling pathway provides a new approach for targeted therapy of malignant tumors.