Study on the anti-RSV mechanism of extracts from Hibiscus mutabilis leaf in vitro

摘要

Objective:To study the anti-respiratory syncytial viruses(RSV) mechanism of extracts from Hibiscus mutabilis leaf in vitro.Methods:Elibavirin was used as the positive drug to detect the anti-RSV activity of extracts from Hibiscus mutabilis leaf. By observing the antiviral effect of the extracts of Hibiscus mutabilis leaf in different ways of administration, the anti-RSV mechanism of the extracts of Hibiscus mutabilis leaf was preliminarily explored.Results:Hibiscus mutabilis leaf extracts could effectively inhibit the cytopathic changes caused by RSV, and had significant antiviral effect. The therapeutic index (TI) was 86.24.Conclusion:Hibiscus mutabilis leaf extracts have significant anti-RSV effect in vitro, and their antiviral effect occurs after virus penetration.