Correlation of AP-4 and EZH2 gene expression with apoptosis and epithelial-mesenchymal transition in endometrial cancer lesions

摘要

Objective: To study the correlation of AP-4 and EZH2 gene expression with apoptosis and epithelial-mesenchymal transition in endometrial cancer lesions. Methods: Patients with endometrial cancer who received surgical resection in Xiaogan First People's Hospital between February 2015 and January 2017 were selected, right amount of endometrial cancer lesion and adjacent lesion was collected to extract RNA, and then the expression of AP-4 and EZH2 gene as well as apoptosis genes and epithelial-mesenchymal transition genes were determined. Results: AP-4 and EZH2 gene mRNA expression in endothelial cancer lesion were greatly higher than those in adjacent lesion; SRPX2, RLIP76, ZEB1, SALL4, TET1, RANKL and N-cadherin mRNA expression in endometrial cancer lesion were greatly higher than those in adjacent lesions whereas Fat-1, ITLN-1, Caspase-3 and -catenin mRNA expression were greatly lower than those in adjacent lesions; SRPX2 and RLIP76 mRNA expression in endometrial cancer lesion with high AP-4 expression were greatly higher than those in endometrial cancer lesion with low AP-4 expression whereas Fat-1, ITLN-1 and Caspase-3 mRNA expression were greatly lower than those in endometrial cancer lesion with low AP-4 expression; ZEB1, SALL4, TET1, RANKL and N-cadherin mRNA expression in endometrial cancer lesion with high EZH2 expression were greatly higher than those in endometrial cancer lesion with low EZH2 expression whereas α-catenin mRNA expression was greatly lower than that in endometrial cancer lesion with low EZH2 expression. Conclusion: The AP-4 and EZH2 gene highly expressed in endometrial cancer lesion can inhibit the apoptosis of cancer cells and promote the epithelial-mesenchymal transition of cancer cells.