Obj ective]To optimize the technology of polysaccharides extration from Ficus carica,and study its health to alloxan-induced diabetic rats function.[Method]Extracting process of polysaccharides from Ficus carica were optimized by response surface methodology and enzymolysis,and investigating the effects of polysaccharides on glucose and lipidemia and acute toxicity in alloxan-induced diabetic rats.[Re-sult]The optimal extraction conditions were hydrolysis temperature of 50.36 ℃,hydrolysis concentration of 0.06 g ,extraction pH of 4.73 and extracting three times.Under the conditions,the predicted and proved value of polysaccharides extracted were 34.47%and 34.13%,respectively.If polysaccharides were contin-uously intragastric administration for 28 days ,the polysaccharides could significantly reduce blood glucose adrenaline induced hyperglycemia in normal rats and could decrease the levels of FBG ,HbAlc,TC and TG in serum in alloxan-induced diabetic rats,and increase the concentrations of HDL significantly.[Conclu-sion]The optimal process parameters for extracting polysaccharides from Ficus carica was obtained ,and the polysaccharides could significantly decrease the blood glucose and improve the disorder of lipid metabo-lism in alloxan-induced diabetic rats.%【目的】优化无花果多糖提取工艺，研究其生物功能．【方法】采用响应面与酶法联用优化无花果（Ficus carica）多糖的提取工艺，测定无花果多糖对糖尿病诱导大鼠血脂代谢指标的影响．【结果】无花果多糖提取最佳优化条件为酶解温度50．36℃，酶用量0．06 g和pH 4．73．该条件下无花果多糖提取预测值为34．47％，验证值为34．13％．用无花果多糖连续给大鼠灌胃给药28 d，发现无花果多糖能显著降低正常大鼠血糖（P＜0．05），极显著降低肾上腺素引起的高血糖（P＜0．01），有效降低糖尿病大鼠的 FBG、HbAlc、TC、TG，升高 HDL含量．【结论】获得了无花果多糖提取最佳工艺参数，无花果多糖能够显著降低糖尿病大鼠血糖，并显著改善糖尿病大鼠血脂代谢紊乱．
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