Objective To summarize clinical characteristic of invasive fungal disease (IFD ) in healthy children and help pediatricians in early diagnosis and improve ment of prognosis. Methods Clinical data of five healthy children with IFD from December, 2009 to October, 2010 were retrospectively analyzed. Results All patients had high fever, chest radiographic changes, and hepatic dysfunction. Candida infection were confirmed by sputum culture in 3 cases, by 1, 3-β-D-glucan ( BG ) test in 2 cases, by blood culture in 2 cases, by bone marrow culture in 2 cases, and by histopathological test in 1 case. All patients recovered by fluconazole treatment. Conclusions IFD lacks specific clinical manifestations in healthy children, and combination of imaging and laboratory tests in needed for diagnosis. Candida infection is the most common cause of IFD. Fluconazole treatment is effective.%目的 总结儿童原发性侵袭性真菌病的临床特点,帮助早期诊断及改善预后.方法 回顾分析2009年12月至2010年10月住院诊断原发性侵袭性真菌病的5例儿童的临床资料.结果 全部患儿均有高热、肺部影像学改变及肝功能异常.痰培养3例阳性,1,3-β-D-葡聚糖(BG)检测2例阳性,血培养2例阳性,骨髓培养2例阳性,组织病理学检查1例阳性.均确认为念珠菌感染,给予氟康唑治疗后痊愈.结论 儿童原发性侵袭性真菌病临床表现缺乏特异性,念珠菌感染常见,需结合影像学及实验室检查进行诊断,氟康唑治疗有效.
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