有上消化道症状患儿幽门螺杆菌感染调查

摘要

Objective To assess the rate of Helicobacter pylori ( H. Pylori) infection in children with upper gastrointestinal symptoms in shanghai. Methods From July 1997 to September 2009, pediatric outpatients with upper gastrointestinal symptoms were recruited All subjects were tested by l3C-Urea Breath Test for diagnosis of H. Pylori infection. Results A total 2 161 pediatric outpatients ( 1 138 males and 1 023 females), aged from 4 years to 16 years, were recruited. Among them, 608 patients were H. Pylori-positive. The total positive rate was 28.14%. The positive rates were significantly different between males ( 361/1 138, 31.72% ) and females ( 247/1 023, 24.14% ) ( X2 = 15.299, P < 0.001 ). From July 1997 to December 2000, 821 patients were tested and the positive rate was 31.18% ( 256/821 ). From January 2001 to December 2004, 713 patients were tested and the positive rate was 28.33% ( 202/ 713 ). From January 2005 to September 2009, 627 patients were tested and the positive rate was 24.56% ( 154/627 ). The positive rates decreased gradually and significantly ( X2 = 7.675, P = 0.022 ). Conclusions There is a gradually downward trend in the rate of H. Pylori infection in children with upper alimentary symptoms in Shanghai.%目的 了解门诊有上消化道症状患儿幽门螺杆菌感染率.方法 对1997年7月至2009年9月,2 161例有上消化道症状的门诊患儿行空腹13C-尿素呼气试验(UBT).结果 2 161例有上消化道症状患儿中男1 138例,女 1 023例,年龄4 ～ 16岁,平均(9.2 ± 5.1)岁.H.Pylori阳性608例,占28.14%,其中男361例(31.72%),女247例(24.14%),差异有统计学意义(χ2 ＝ 15.299,P ＜ 0.001).1997 年7月 - 2000年共检测821例,H.Pylori阳性256例(31.18%),2001年 - 2004年检测713例,H.Pylori阳性202例(28.33%),2005年 - 2009年9月检测627例,H.Pylori阳性154例,(24.56%),感染率有逐年下降趋势,差异有统计学意义(χ2 ＝ 7.675,P ＝ 0.022).结论 门诊中有上消化道症状儿童H.Pylori感染率有逐年下降趋势.