Obesity in today's society has become a worldwide social and health problems. Its mechanism is not very clear, generally regarded hy the genetic and environmental faetors mediated. Snme seholars use the human genomewide association study found that insulin indueed gene 2, body fat content and obesity-relaled gene, Melanocortin-4-receptor genes and body mass index (BMI) is closely related. However, some specific functions of these genes has not revealed clear, there are some ethnic differences and genetic heterogeneity and other issues. Recent study found that environmental factots, the incidence of intestinal flora and obesity are related. Metabolism of intestinal flora with specific performance of decomposition of nutrients for the host to provide energy substrate. Some scholars study suggests that the imbalance of the ratio of intestinal bacteria baeteroides/firmicutes in the development of obesity plass an important role. This article on the current domestic and foreign intestinal flora associated with obesity studies are reviewed.%当今社会,肥胖已经成为一个世界范围内的社会和健康问题,其发病机制普遍认为是由遗传与环境因素共同介导.有学者利用人类全基因组关联研究发现,胰岛素诱导基因2、体脂量和肥胖症相关基因、黑皮质素-4-受体基因等基因与体质指数(BMI)密切相关.但这些基因中有些具体功能还未揭示清楚,有些存在着种族差异及遗传异质性等问题.近年的研究发现环境因素中肠道菌群与肥胖的发病有一定的相关性.众所周知,肠道菌群具有特异的代谢效能,为宿主分解营养物质,提供能量底物.近年有学者研究认为肠道菌群中拟杆菌门/硬壁菌门的比例失调在肥胖的发生发展中有重要作用.该文就当前国内外相关肠道菌群与肥胖的关联性研究作一综述.
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