青春期多囊卵巢综合征患者血清超敏C反应蛋白与I临床各因素的相关性分析

摘要

Objective To explore the correlation between serum highly sensitive C-reactive protein levels and the clinical factors in adolescents with polycystic ovary syndrome (PCOS). Methods Thirty-six girls with PCOS and 15 age-matched normal controls were recruited. In 36 girls with PCOS, 17 were obese (BMI ≥ 25 kg/m2) and 19 were non-obese (BMI < 25 kg/m2). The serum hs-CRP, sex hormone, TC and TG, insulin and glucose level were tested. Results Obese teenagers with PCOS had a significantly higher hs-CRP levels than non-obese teenage with PCOS (P < 0.05) and control group (P < 0.01). Spearman correlations revealed significant positive correlations of hs-CRP with BMI, waist hip ratio (WHR), testosterone and TG (P < 0.05) in all teenagers. The hs-CRP was found to have no correlations with HOMA-IR and ISI (P > 0.05). Conclusions The present study demonstrates that obese teenagers with polycystic ovary syndrome may be in a low-grade inflammation status, which is characterized by elevated levels of C-reactive protein (CRP). Furthermore, CRP reflects the severity of obesity and hyperandrogenmia.%目的 探讨青春期多囊卵巢综合征(PCOS)患者血清中超敏C反应蛋白(hs-CRP)水平与临床各因素之间的相关性.方法 选择36例PCOS患者,17例为PCOS肥胖组(BMI≥25 kg/m2),19例PCOS非肥胖组(BMI＜ 25 kg/m2),另选15例正常少女为对照组.检测血清hs-CRP、性激素、血脂、血糖、胰岛素等,并进行比较和相关性分析.结果 PCOS肥胖组患者的hs-CRP水平明显高于PCOS非肥胖组(P＜0.05)和正常对照组(P＜0.01).Spearman相关分析显示,hs-CRP与BMI、腰臀比、睾酮、三酰甘油呈正相关(P均＜0.05)；与胰岛素抵抗指数、胰岛素敏感指数无相关性(P均＞ 0.05).结论 PCOS肥胖患者体内可能存在着慢性低强度炎症,CRP可以反应其肥胖和高雄激素血症的严重程度.