IgA肾病患者单核细胞趋化蛋白-1含量及其意义

摘要

目的 探讨IgA肾病患者血液、尿液中单核细胞趋化蛋白-1(MCP-1)的含量变化及其临床意义.方法 选取20例8～ 18岁IgA肾病患者为实验组,20例健康体检者为对照组.用流式细胞仪检测两组血液中CD14+单核细胞的含量；采用酶联免疫吸附法( ELISA)检测血液、尿液MCP-1的含量,并进行比较.结果 IgA肾病患者血液中CD14+单核细胞的含量低于对照组,差异有统计学意义(P＜0.01).其尿液中MCP-1的含量较对照组明显增高,差异有统计学意义(P＜0.01),而其血液MCP-1的含量与对照组比较差异无统计学意义(P＞0.05).结论 IgA肾病的发病与趋化因子MCP-1有关.监测尿液MCP-1的浓度可望作为临床上评价IgA肾病肾小管间质功能的一项无创伤性指标.%Objective To study the concentration of serum and urine monocyte chemoattractant protein-1 in patients with IgA nephropathy and its clinical significance. Methods Twenty patients with IgA nephropathy aged 8 to 18 years were enrolled as experimental group, while 20 healthy volunteers were enrolled as control group. The level of blood CD14+ monocytes was measured by flow cytometery. The level of serum and urine MCP-1 were detected by ELISA. Results The level of blood CD14+ monocytes in patients with IgA nephropathy was significantly lower than control group (P < 0.01). The urine concentration of MCP-1 in patients with IgA nephropathy significantly increased than control group (P < 0.01). There was no significant difference of the serum concentration of MCP-1 between patients with IgA nephropathy and control group. Conclusions The onset of IgA nephropathy was related with MCP-1. Monitoring urine concentration of MCP-1 is expected to serve as a non-invasive indicator to evaluate tubulointerstitial function of IgA nephropathy in clinical.