炎症性肠病与血管生成因子

摘要

炎症性肠病(inflammatory bowel disease,IBD)是一种肠道非特异性的慢性炎性疾病.近年来的研究表明,血管生成在肿瘤和慢性炎症中起重要作用,因而有关IBD发生发展中血管生成的研究日益受到重视.现就IBD血管生成研究中热点的促血管生成相关因子,血管内皮生长因子、碱性成纤维细胞生长因子、血管生成素、血小板衍生生长因子等的研究进展作一综述.%Inflammatory bowel disease (IBD) is a chronic inflammation of intestinal tract. Recent studies increasingly suggest that angiogenesis plays an important role in the pathology of tumors and chronic inflammations. Angiogenesis in the generation and development of IBD is gaining more and more attention. This review discusses the interrelationship between IBD and the related factors which promote angiogenesis, such as vascular endothelial growth factor, basic fibroblast growth factor, transforming growth factor beta, platelet-derived growth factor and so on.