肺炎支原体感染婴幼儿血清免疫球蛋白、补体及促炎/抗炎细胞因子水平的动态变化

摘要

Objective To investigate the changes in serum concentration of immunoglobulin, complement and cytokines concentrations during acute and recovery phase of mycoplasma pneumonia (MPP) in infants. Methods Sixty infants with MPP and 60 healthy control infants were enrolled. The levels of serum immunoglobulins (IgM, IgG, IgA) and complements (C3, C4) were detected using immune scatter turbidimetry, and the levels of TNF-α, IL-8, IL-10, and IL-13 were determined by ELISA. Results Compared with infants in the recovery phase and healthy control infants, the levels of IgM, C3, C4, TNF-a, IL-8 and IL-13 were significantly higher in the acute phase (P＜0.05), and the levels of IgA and IL-10 were significantly lower (P＜0.05), while there was no statistical difference in the levels of IgG between the infants in the acute phase and healthy infants (P＞0.05). Conclusions The detection of the changes of immunoglobulins, complements, pro- and anti-inflammatory cytokines is valuable to assessing the severity of disease and the prognosis of MPP in infants.%目的 探讨婴幼儿肺炎支原体肺炎(MPP)急性期与恢复期免疫功能的变化.方法 入选MPP患儿60例,正常对照儿童60例,采用免疫散射比浊法测定免疫球蛋白(IgM、IgG、IgA)及补体C3、C4水平；ELISA法测定血清TNF-α、IL-8、IL-10、IL-13水平.结果 MPP患儿急性期IgM,补体C3、C4,TNF-α,IL-8,IL-13水平均高于恢复期或正常对照儿童,差异有统计学意义(P均＜0.05)；MPP患儿急性期IgG水平与正常对照儿童比较,差异无统计学意义(P＞0.05),IgA和IL-10水平均低于恢复期和正常对照儿童,差异有统计学意义(P均＜0.05).结论 检测MPP患儿免疫球蛋白、补体及促炎/抗炎细胞因子水平的动态变化对判定病情和预后有一定的临床意义.