认识嗜酸细胞性食管炎——从基因学、免疫学到临床诊治

摘要

在欧美国家中,嗜酸细胞性食管炎已成为一种常见的以严重嗜酸性粒细胞浸润为主的消化道疾病.其发病和食物过敏、支气管哮喘、特应性皮炎及其他过敏性疾病密切相关.Th2细胞在疾病的慢性炎症中起到了至关重要的作用.文章拟综述嗜酸细胞性食管炎的基础研究进展及临床治疗.%In Europe and the United States, eosinophilic esophagitis (EoE) has become a common gastrointestinal disease characterized by severe eosinophil infiltration in the esophagus. It is strongly associated with food allergy, asthma, atopic dermatitis, and other allergic diseases. T lymphocytes, especially Th2 cells, play an instrumental role in the development of allergic inflammation. In this review, the current understanding of EoE and its treatment options will be discussed.