川崎病(KD)是一种以全身血管炎为主要病理变化的疾病,好发于5岁以下的婴幼儿,其发病机制至今尚未完全阐明.细胞因子是由多种细胞特别是免疫细胞产生的具有免疫调节和效应功能的蛋白质或小分子多肽.研究表明,KD患儿免疫系统处于激活状态,多种细胞因子水平存在明显异常,并参与KD发生发展的过程,某些细胞因子基因多态性与KD易感性、并发冠状动脉损害及难治性KD有关.现就多种细胞因子水平在KD中的变化及其在KD中的作用进行综述,并重点探讨与KD相关的细胞因子基因多态性.%Kawasaki disease (KD) is a systemic vasculitis of unknown etiology, most often affecting children under 5 years old. Cytokines are a group of proteins and small molecular peptides produced by different cells, especially cells of the immune system and have the effects on immune regulation. Studies have shown that the immune system of children with KD is activated and the levels of a variety of cytokines change significantly, which are involved in the development of KD. Genetic polymorphisms in some cytokines are associated with the susceptibility to KD and the occurrence of coronary artery lesions and the refractory KD. The roles of cytokines and changes of cytokine levels in KD are reviewed in this article. Genetic polymorphisms of cytokines associated with KD are also discussed.
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