病毒性心肌炎基因易感性研究进展

摘要

病毒性心肌炎(VMC)是由病毒感染和自身免疫反应共同引起的一种急性或慢性心肌炎性疾病，其最终能够导致扩张性心肌病并伴有危及生命的症状，如心律失常、心力衰竭及突发性心肌梗死等。目前，对于VMC的发病机制尚未完全阐明。据初步研究表明，VMC发病与基因的易感性有关。%Viral myocarditis is an acute or chronic inlfammatory disease of the myocardium and may progress to dilated cardiomyopathy (DCM) with life-threatening symptoms including heart failure, arrhythmias and sudden cardiac death. At present, the pathogenesis of viral myocarditis still remains unclear, so it is dififcult for clinicians to diagnose, treat and ifnd a speciifc biomarker. However, the pilot researches showed that pathogenesis of viral myocarditis was associated with genetic susceptibility. This article reviewed the above aspects.