瓜氨酸、肠型脂肪酸结合蛋白、肠三叶因子在儿童危重症急性胃肠损伤诊断中的作用

摘要

目的：比较血清瓜氨酸、肠型脂肪酸结合蛋白(IFABP)和肠三叶因子(ITF)在儿童危重症急性胃肠损伤诊断中的价值。方法入选84例危重症患儿，应用高效液相色谱法检测血清瓜氨酸，酶联免疫吸附法检测血清IFABP、ITF，结合临床资料进行比较分析。结果胃肠损伤组血清瓜氨酸水平低于非胃肠损伤组，血清IFABP、ITF水平高于非胃肠损伤组，差异有统计学意义(P均<0.05)；危重症患儿血清瓜氨酸与反应蛋白(CRP)、降钙素原(PCT)、住院时间呈显著负相关(r=－0.36~－0.31，P均<0.01)。结论血清瓜氨酸、IFABP、ITF对危重症患儿急性胃肠损伤均有一定的诊断价值，瓜氨酸水平可能反映危重病患儿胃肠损伤程度。%ObjectiveTo compare the values of serum citrulline, intestinal fatty acid binding protein (IFABP) and intes-tinal trefoil factor (ITF) in diagnosis of acute gastrointestinal injury in critically ill children.MethodsA total of 84 critically ill children were enrolled. The serum citrullin, IFABP, and ITF were measured by high performance liquid chromatography and enzyme-linked immunosorbent assay. The testing results and clinical data were analyzed.ResultsCompared with non gastroin-testinal injury group, the serum citrulline level was signiifcantly lower and IFABP and ITF levels were signiifcantly higher in gas-trointestinal injury group (allP<0.05). In critically ill children, the serum citrulline level was negatively correlated with C-reactive protein, procalcitonin and hospitalization time (r=-0.36 to -0.31,P<0.01).ConclusionsThe levels of citrulline, IFABP and ITF have diagnostic values for acute gastrointestinal injury in critically ill children. The level of citrulline may relfect the degree of acute gastrointestinal injury in critically ill children.