双酚A与女童性早熟的关系

摘要

Objective To study the relationship between bisphenol A and precocious puberty in 6-8 years girls. Meth-ods Atotal of 103 girls aged 6-8 years with precocious puberty in our Endocrine clinic from August to December 2012 were se-lected. According to the classiifcation standard of precocious puberty, girls are divided into idiopathic central precocious puberty (ICPP) group (n=47) and permature thelarche (PT) group (n=56), 53 girls with no puberty development were chosen as control group. BPA concentrations were determined with HPLC-MS-MS, sex hormones were determined with chemiluminescence meth-od and Kisspeptin concentrations were determined with ELISA, then the differences among the three groups were compared and the relationships between bisphenol A and sex hormones and Kisspeptin were analyzed. Results The BPA relevance ratio and concentration in ICPP group were higher than those of PT group and control group (P<0.05). The peak concentration of LH and LH/FSH in ICPP group were higher than those of PT group (P<0.05). The concentration of E2 in ICPP group and PT group were higher than that of control group (P<0.05). The concentration of Kisspeptin in ICPP group was higher than that of PT group and control group (P<0.05). There were no relationship between the concentrations of bisphenol A and Kisspeptin and FSH peak con-centration (P>0.05). There were correlations between the concentrations of BPA and E2 and LH peak concentration and LH/FSH (P<0.05). Conclusions There is a certain correlation between the concentrations of BPA and ICPP.%目的：探讨双酚A(BPA)与女童性早熟的关系。方法选择2012年8月至12月就诊的103例6~8岁性早熟女童，根据性早熟分类标准分为特发性中枢性性早熟(ICPP)组(n=47)及单纯乳房发育(PT)组(n=56)，选取同期同年龄乳房未发育女童53例为正常对照组。高效液相色谱串联质谱法(HPLC-MS-MS)测定血清BPA，酶联免疫法测定血清Kisspeptin，化学发光法测定血清性激素，比较和分析三组间的差异。结果 ICPP组和PT组的血清BPA检出率高于对照组，ICPP组血清BPA水平高于PT组及对照组，差异有统计学意义(P均<0.05)；ICPP组血清Kisspeptin水平也高于PT组及对照组，差异有统计学意义(P均<0.05)；ICPP组血清黄体生成素(LH)峰值及LH/卵泡刺激素(FSH)比值高于PT组，ICPP组及PT组血清雌二醇(E2)水平高于对照组，差异有统计学意义(P均<0.05)。三组的血清BPA水平与E2、LH峰值及LH/FSH比值有相关性(P<0.05)，与血清Kisspeptin水平及FSH峰值无相关性(P>0.05)。结论 BPA与女童ICPP发生有一定的相关性。