Objective To analyze the clinical features and bacterial drug resistance of severe sepsis caused by methicil-lin-resistant Staphylococcus aureus (MRSA) infections in children. Methods The clinical data and results of antibiotic suscep-tibility test in 12 children with severe sepsis caused by MRSA infections from January 2010 to December 2013 were analyzed retrospectively. Results Among 12 children, there were 5 boys and 7 girls. Their age ranged from 8 days to 11 years, with a me-dian age of 1 year and there were 9 infants. All cases presented with acute onset which included 5 cases of acute osteomyelitis or purulent arthritis, 5 cases of necrotizing pneumonia with pyothorax, one case of necrotizing fasciitis and one case of bloodstream infection. 8 cases were complicated by skin and soft tissue infection, 7 cases by septic shock and 1 case by disseminated intravas-cular coagulation. The levels of C-reactive protein were increased in all children and white blood cell counts were decreased in 4 children. The susceptibility testing showed MRSA was sensitive to vancomycin and linezolid, and resistant to erythromycin, clin-damycin and compound sulfamethoxazole. After treatment with surgical debridement and closed-chest drainage, 8 cases survived and 4 cases died. Conclusions The severe sepsis caused by MRSA infections was common in infants with sudden onset and rapid progress, so active treatments are needed.%目的：分析儿童耐甲氧西林金黄色葡萄球菌(MRSA)感染导致严重脓毒症的临床特点及细菌耐药性。方法回顾性分析2010年1月至2013年12月收治的12例MRSA感染致严重脓毒症患儿的病史和细菌药敏试验资料。结果12例患儿中，男5例、女7例，年龄8 d~11岁，中位年龄1岁，9例为<1岁婴儿，均急性起病。5例表现为急性骨髓炎和/或化脓性关节炎，5例表现为坏死性肺炎伴脓胸，1例表现为坏死性筋膜炎，1例表现为血流感染；其中8例同时伴有皮肤及软组织感染，7例并发脓毒性休克，1例并发弥漫性血管内凝血。患儿C反应蛋白均显著升高，4例白细胞计数下降。药敏试验显示12株MRSA对万古霉素、利奈唑胺均敏感，对红霉素、克林霉素、复方磺胺甲噁唑有不同程度的耐药。经手术清创、胸腔闭式引流等治疗后，8例存活，4例死亡。结论 MRSA感染导致的严重脓毒症多见于婴儿，发病急、进展迅速，需要积极治疗。
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