Objective To study the relationship between ARID5B polymorphisms and the susceptibility of the childhood acute lymphoblastic leukemia (ALL) in Minnan Chinese Han population. Methods The association analysis between ALL and polymorphisms of ARID5B were performed in a Minnan Han population case-control series using lfuorescence resonance energy transfer probes analysis. Results We analyzed the genotypes of the rs7073837 and rs10821936 in ARID5B in 108 patients with acute lymphoblastic leukemia and 116 ethnically matched controls. The genotype distribution of rs7073837 and rs10821936 in ALL and control groups followed Hardy-Weinberg equilibrium. No signiifcant differences in genotypic and allelic distributions between ALL patients and controls were observed for rs7073837. We found signiifcant differences in genotypic distribution of rs10821936 variant between ALL patients and control subjects (P<0.001), and variant allele C in ALL group was signiifcantly more frequent than that in the controls (P<0.001, Odds ratio=2.203, 95%conifdence interval, CI:1.507-3.220). Conclusions Our data suggested that rs10821936 variant in ARID5B plays a potential role in childhood ALL in Minnan Han population, and variant allele C carriers may be at an increased risk of developing ALL. Moreover, no association between rs7073837 and child-hood ALL was observed.%目的：探讨ARID5B基因常见单核苷酸多态性与闽南地区汉族儿童急性淋巴细胞白血病的相关性。方法采用病例-对照研究，对108例急性白血病患儿及116名年龄、性别、种族匹配的对照人群中的ARID5B基因rs7073837和rs10821936多态位点用荧光能量共振转移技术进行检测，分析不同基因型与儿童急性白血病的易感性。结果两位点在两组人群中的基因频率分布符合Hardy-Weinberg平衡(P均>0.05)。多态性位点rs7073837在两组间的基因型和等位基因频率分布的差异无统计学意义(P均>0.05)；病例组rs10821936位点与对照组相比，TT、TC、CC基因型频率的差异有统计学意义(P<0.001)，ALL组等位基因C频率高于对照组，差异有统计学意义(χ2=16.833，P<0.001)，提示等位基因C是ALL发生的危险因素(OR=2.203，95% CI：1.507-3.220)。结论 ARID5B基因rs10821936位点是闽南地区汉族儿童急性白血病的一个危险因素，携带突变基因序列C的个体可增加急性白血病的发病风险；而多态性位点rs7073837可能与儿童急性白血病人群无关。
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