新生儿重症监护病房多重耐药菌感染危险因素logistic回归分析

摘要

Objective To analyze risk factors of multiple drug-resistant infections in neonatal intensive care unit (NICU). Methods The clinical data from 284 hospitalized pediatric patients were retrospectively analyzed from June 2011 to July 2015 . The differences between 59 cases with multiple drug-resistant infections and 225 cases with non-multiple drug-resistant infections were compared and analyzed by logistic regression. Results All of 284 cases were single birth. Fifty-nine cases ( 13 . 13 ± 9 . 03 days old) had multiple drug-resistant infections, in which 42 were males and 17 were females. Two hundred and twenty-ifve cases ( 14 . 21 ± 8 . 34 days old) had non-multiple drug-resistant infections, in which 175 cases of males and 50 cases of females. Single factor analysis showed that 8 factors, including gestational age, birth weight, days in hospital, Apgar score at birth, mechanical ventilation, parenteral nutrition, and the categories and duration of use of antimicrobial agents, were the risk factors of multiple drug-resistant infections (P < 0 . 05 ). Logistic regression analysis showed that the birth weight and the categories and duration of use of antimicrobial agents were the dominant factors that caused multiple drug-resistant infections in NICU (P < 0 . 05 ). Conclusions Effective prevention and control measures should be taken to reduce the multiple drug-resistant infection in NICU.%目的：分析新生儿重症监护病房（NICU）多重耐药菌感染的危险因素。方法回顾性分析2011年6月至2015年7月284例NICU住院患儿的临床资料，比较59例多重耐药菌感染与225例非多重耐药菌感染患儿的差异，并进行多因素logistic分析。结果284例患儿均为单胎。59例多重耐药菌感染患儿，男42例、女17例，日龄（13.13±9.03）d；225例非多重耐药菌感染患儿，男175例、女50例，日龄（14.21±8.34）d。单因素分析显示，患儿胎龄、出生体质量、住院天数、出生时Apgar评分、机械通气、使用肠外营养、使用抗菌药物种类及持续时间8个因素是患儿多重耐药菌感染的危险因素（P < 0.05）；多因素分析显示，出生体质量、联合使用抗菌药物及抗菌药物使用持续时间是NICU患儿多重耐药菌感染的最主要因素（P < 0.05）。结论应针对相关危险因素采取有效防控措施，减少NICU患儿多重耐药菌感染。